Composition and Mechanism
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Profhilo contains 64mg hybrid HA (32mg HMW 2MDa + 32mg LMW 80-120kDa) stabilised via thermal process (no BDDE chemical cross-linking), enabling 30x slower enzymatic degradation vs standard HA. This unique blend of high molecular weight and low molecular weight hyaluronic acid sets it apart from traditional dermal fillers. Dermal fillers often use cross-linked HA for volume, while Profhilo focuses on bio-remodelling.
The exact composition ensures structural support from HMW HA and deep hydration from LMW HA. Below is a breakdown of Profhilo's components:
| Component | Amount | Molecular Weight | Primary Function |
|---|---|---|---|
| HMW HA | 32mg | 2 million Daltons | Structural support |
| LMW HA | 32mg | 80-120kDa | Hydration |
Profhilo's mechanism promotes collagen and elastin stimulation through bio-remodelling, spreading evenly under the skin for natural rejuvenation. Unlike fillers that stay put for volume restoration like cheek enhancement, Profhilo diffuses to improve skin firmness and elasticity. The treatment uses the BAP technique with 5 precise face points, spaced 2cm apart, for even distribution.
Thermal stability allows Profhilo to maintain integrity at body temperature, unlike standard uncrossed HA that breaks down quickly. This supports longer-lasting effects in skin hydration and wrinkle reduction. Experts recommend it for patients seeking glowy skin without the lumpiness of fillers.
Types and Ingredients
Juvederm Ultra (24mg HA/ml, Vycross tech), Restylane Kysse (20mg HA/ml, NASHA), Teosyal RHA (23mg HA/ml, resilient chains) represent leading BDDE-crosslinked fillers. These dermal fillers use hyaluronic acid cross-linking to enhance treatment duration and stability. In contrast, Profhilo employs high-concentration uncrossed hyaluronic acid for bio-remodeling.
Profhilo contains 64mg of hyaluronic acid per 2ml syringe, stabilised thermally without chemical agents like BDDE. This formulation promotes collagen stimulation and elastin production, differing from traditional fillers focused on volume restoration. Experts recommend it for patients seeking skin hydration and firmness over targeted contouring.
G-prime ratings measure cohesivity, indicating how well a filler holds shape under stress. Juvederm Voluma has a G-prime of around 300Pa, offering smooth integration for cheek enhancement, while Restylane Lyft reaches 450Pa for firmer lift in jawline contouring. Higher values suit areas needing structural support.
| Brand | HA Concentration | Cross-link Tech | G-prime (Cohesivity) | Duration |
|---|---|---|---|---|
| Juvederm Voluma | 24mg/ml | Vycross | 300Pa | 6-18 months |
| Restylane Lyft | 20mg/ml | NASHA | 450Pa | 12 months |
| Belotero Balance | 22.5mg/ml | CPM | ~500Pa | 6-12 months |
| Juvederm Ultra | 24mg/ml | Vycross | ~200Pa | 9-12 months |
| Restylane Kysse | 20mg/ml | NASHA | ~300Pa | 9-12 months |
All listed fillers hold FDA approval and CE marks for facial aesthetics, ensuring safety in minimally invasive treatments. Profhilo also carries these certifications, supporting its use in skin boosters and biorevitalization. Consult a qualified injector to match types to goals like wrinkle reduction or skin elasticity.
What is Profhilo?
Profhilo represents next-gen bio-remodeling with its patented NAHYCO technology combining 32mg High Molecular Weight HA + 32mg Low Molecular Weight HA for optimal tissue diffusion. This hybrid formula sets it apart from traditional dermal fillers. It focuses on collagen stimulation and skin hydration rather than just volume.
Profhilo's innovation lies in hybrid-collagen stimulation across 5 BAP injection points versus traditional filler placement. The BAP technique uses fewer, strategic points for even spread. This minimally invasive approach promotes skin firmness and elasticity.
Unlike fillers that target specific areas like cheek enhancement or lip augmentation, Profhilo diffuses across the face for overall skin rejuvenation. It treats skin laxity and fine lines through bio-remodeling. Patients often notice a glowy skin effect after sessions.
The standard protocol involves a 2-session treatment at a 4-week interval, with a 6-month booster for maintenance. It's suitable for face protocol, neck, hands, and decolletage. Consult a qualified injector to assess suitability for anti-aging needs.
What are Dermal Fillers?
Dermal fillers deliver targeted volume using BDDE cross-linked HA gels that stay precisely where injected for structural support. These injectable treatments restore lost fullness in areas like cheeks or lips. Unlike Profhilo's diffuse biorevitalization approach, fillers provide immediate volume via precise placement in dermal or subdermal layers.
Common uses include lip augmentation, cheek enhancement, and filling nasolabial folds or marionette lines. Practitioners inject them to smooth fine lines and wrinkles or contour the jawline. This offers quick volume restoration for a lifted, youthful look.
Hyaluronic acid cross-linking with BDDE gives fillers their durability and shape. They resist breakdown, supporting skin firmness and elasticity. Results last several months, depending on the product and area treated.
Choose a qualified injector like a dermatologist for natural results. Discuss goals during a clinic consultation to avoid issues like filler migration or lumpiness. These non-surgical options suit mature skin with mid-face volume loss.
Key Differences in Composition
Profhilo's thermal stabilisation (no BDDE) vs fillers' chemical cross-linking creates fundamentally different tissue interactions: bioremodelling vs volumising. This distinction in hyaluronic acid processing affects how each treatment interacts with skin layers during injectable treatments. Patients seeking skin rejuvenation notice varied outcomes based on these core differences.
Uncrossed hyaluronic acid in Profhilo spreads through diffusion technology, promoting collagen stimulation and elastin production. Dermal fillers, with BDDE cross-linking, stay localised to provide volume restoration in areas like cheeks or lips. Choose based on goals such as skin hydration or wrinkle reduction.
The stability pyramid concept illustrates Profhilo's layered thermal bonds for slow, natural degradation, contrasting fillers' rigid chemical structure. This leads to differences in treatment duration and results longevity. Experts recommend consulting a qualified injector to match composition to needs like skin firmness or fine lines.
For facial aesthetics, Profhilo suits diffuse skin laxity, while fillers target nasolabial folds or jawline contouring. Real-world examples include using Profhilo for a radiant complexion on the neck, versus fillers for lip augmentation. Both offer non-surgical anti-aging with minimal downtime.
| Aspect | Profhilo | Dermal Fillers |
|---|---|---|
| Cross-linking | None/Thermal | BDDE |
| Degradation | 30x slower | 2-3x |
| Mechanism | Bio-remodelling | Volumetric |
| Concentration | 64mg/syringe | 20-26mg/ml |
| Injection volume | 3ml total | 1-4ml targeted |
Treatment Process and Application
Profhilo treatment takes 15-20 minutes using 5 BAP points per side (29G needle, 0.2ml/point) vs fillers' 30-45 minutes with multiple targeted injections (27G cannula/needle). This difference highlights Profhilo's streamlined BAP technique, which spreads hyaluronic acid for bio-remodeling. Dermal fillers focus on precise volume placement for targeted areas.
The Profhilo protocol follows a numbered sequence for efficiency. First, cleanse the skin thoroughly. Then mark the 10 BAP points across both sides of the face, injecting 2ml per side at 5 points each, followed by gentle massage for even diffusion.
Dermal fillers use a more layered approach for volume restoration. Apply numbing cream for 20 minutes, create cannula entry points, and employ a fanning technique to build structure in areas like cheeks or lips. This allows customisation but extends session time.
Both are minimally invasive injectables, yet Profhilo prioritises skin hydration and collagen stimulation over fillers' wrinkle reduction and contouring. Patients often prefer Profhilo's quick process for busy schedules in facial aesthetics.
Profhilo Protocol
The BAP technique in Profhilo refers to Bio Aesthetic Points, a clinical protocol for optimal hyaluronic acid spread. It uses 10 specific points on the face to treat skin laxity without excessive injections. This method promotes skin firmness and elasticity through uncrossed hyaluronic acid diffusion.
Follow these steps in a typical session:
- Cleanse and disinfect the treatment area.
- Mark the 5 BAP points per cheek and jawline.
- Inject 0.2ml of Profhilo at each point using a 29G needle.
- Massage lightly to aid diffusion technology.
This 2-session protocol at 4-week intervals boosts results longevity. A 6-month booster maintains glowy skin and radiant complexion. Experts recommend qualified injectors for safe bio-remodeling.
Dermal Fillers Application
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Dermal fillers involve targeted injections of cross-linked hyaluronic acid for volume and structure. Use a 27G cannula or needle to minimise bruising in areas like nasolabial folds or marionette lines. The process builds layers for natural results in cheek enhancement or jawline contouring.
Standard steps include:
- Apply numbing cream and wait 20 minutes.
- Mark 1-3 cannula entry points per area.
- Employ layered fanning technique for even distribution.
- Mould the product for smooth integration.
Treatment adapts to patient needs, such as mid-face lifting or chin projection. Combination therapy with Profhilo enhances skin boosters effects. Downtime remains low for non-surgical anti-aging.
| Treatment | Duration | Key Tools |
|---|---|---|
| Profhilo | 15-20 minutes | 29G needle, BAP points |
| Dermal Fillers | 30-45 minutes | 27G cannula/needle, fanning |
The table shows clear contrasts in treatment duration and tools. Profhilo's simplicity reduces side effects risk, while fillers offer precision at a longer time cost. Choose based on goals like skin hydration versus volume restoration.
Primary Uses and Target Areas
Profhilo treats diffuse skin laxity across cheeks, midface and neck via BAP diffusion while fillers target structural deficits like 2-3ml cheek augmentation or 1ml nasolabial fold correction. This core difference in approach defines their roles in facial aesthetics. Profhilo focuses on overall skin rejuvenation through bio-remodelling.
Dermal fillers excel in volume restoration for specific zones like lips, cheeks or jawline. They use cross-linked hyaluronic acid to add structure and contour. Common examples include 1ml for lip augmentation or 2-4ml for jawline contouring.
Profhilo suits broader areas such as neck, hands and décolletage for skin firmness and hydration. It spreads via five BAP points per side of the face, promoting collagen stimulation and elastin production. Patients often notice improved skin quality after treatment.
In contrast, fillers require precise layering in targeted spots like tear troughs with 0.5ml or under-eye hollows. This makes them ideal for mid-face lifting or chin projection. Choose based on whether you need diffuse improvement or focal enhancement.
Profhilo Target Areas and BAP Technique
Profhilo uses the BAP technique with five injection points per cheek and neck side for even diffusion. This allows uncrossed hyaluronic acid to spread naturally, treating skin laxity without volume overload. Ideal for cheeks, midface and neck.
Extend to hands rejuvenation, décolletage or even body areas like arms and knees for skin tightening. The face protocol involves two sessions four weeks apart. Results enhance skin elasticity and hydration over time.
Biorevitalization occurs as Profhilo stimulates fibroblasts for natural glowy skin. Suitable for mature skin with crepey texture or sagging jowls. Avoid if seeking sharp contouring.
Dermal Fillers Target Areas and Layering
Fillers target structural deficits with precise volumes, such as 2ml for cheek enhancement or 1ml for nasolabial folds. Layering builds from deep to superficial for natural results. Jawline needs 2-4ml for contouring.
Lips use about 1ml for plumpness, while tear troughs take 0.5ml to fill hollows. Brands like Juvederm or Restylane vary by cross-linking for longevity. Marionette lines or smoker lines respond well too.
Treatment suits volume loss from fat pad descent or bone resorption. Expect minimal downtime but watch for lumpiness or migration. Combine with Profhilo for comprehensive anti-aging.
| Treatment | Primary Uses | Typical Volumes/Areas |
|---|---|---|
| Profhilo | Diffuse bioremodelling, skin hydration | Cheeks, neck, hands (5 BAP points/side) |
| Dermal Fillers | Targeted volume, contouring | Lips (1ml), cheeks (2ml), jawline (2-4ml) |
Results: Duration and Appearance
Profhilo delivers progressive glow peaking at week 4 and lasting 6 months, while dermal fillers provide immediate volume that endures 12-18 months depending on placement and motion. This core difference in results longevity shapes patient expectations for skin rejuvenation. Choose based on whether you seek quick volume restoration or gradual bio-remodelling.
With Profhilo, the 2-session protocol at a 4-week interval sparks collagen stimulation and elastin production for improved skin firmness and elasticity. Patients notice enhanced hydration from the first treatment, building to a radiant complexion by session two. This non-surgical approach suits those targeting skin laxity without adding bulk.
Dermal fillers, using hyaluronic acid cross-linking with BDDE, offer instant lift for areas like cheek enhancement or lip augmentation. Results appear natural yet defined, addressing mid-face volume loss from fat pad descent or bone resorption. Maintenance varies by active zones like nasolabial folds or jawline contouring.
Both injectable treatments minimise downtime, but Profhilo's diffusion technology via the BAP technique ensures even spread across five injection points per cheek. Fillers target precise dermal layers for wrinkle reduction and fine lines. Consult a qualified injector to match treatment to your aging process.
Timeline Comparison
| Treatment | Session 1 | Session 2 (Week 4) | Peak Results | Duration |
|---|---|---|---|---|
| Profhilo | Hydration boost | Peak biostimulation | Week 4 glow | 6 months |
| Dermal Fillers | Immediate 100% volume | Not applicable | Instant lift | 12-18 months |
The timeline comparison highlights Profhilo's gradual build-up versus fillers' swift impact. Profhilo's uncrossed hyaluronic acid spreads thermally stable effects for biorevitalization. Fillers deliver targeted projection right away.
Experts recommend Profhilo for young skin seeking glowy, plump skin without volume. Fillers excel in mature skin with sagging jowls or hollow cheeks. Track progress with before-after photos during clinic consultations.
Appearance Metrics and Expectations
Profhilo enhances skin quality through bio-remodeling, yielding very improved texture and firmness. Dermal fillers provide measurable lift, such as added projection in cheeks. These appearance metrics guide realistic outcomes in facial aesthetics.
| Aspect | Profhilo | Dermal Fillers |
|---|---|---|
| Before | Dull, lax skin | Flat cheeks, hollows |
| After | Glowy, elastic skin | Lifted, contoured face |
| Key Change | Skin hydration, firmness | Volume, projection |
This before-after expectation table sets practical goals for anti-aging. Profhilo avoids overfilled looks or filler migration risks. Fillers risk lumpiness or Tyndall effect if misplaced, reversible with hyaluronidase.
For combination therapy, pair Profhilo with fillers like Juvederm or Restylane for comprehensive results. Ideal for neck treatment, hands rejuvenation, or body areas like knee laxity. Discuss patient suitability with your dermatologist.
Downtime, Side Effects, and Safety
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Both Profhilo and dermal fillers are minimally invasive, but Profhilo shows 5 small BAP bumps with 24-hour resolution, versus fillers' bruising and swelling for 3-7 days, plus a rare vascular occlusion risk.
Profhilo uses the BAP technique with just five injection points per side of the face. This leads to tiny marks that fade quickly, allowing most patients to return to normal activities the same day. In contrast, dermal fillers often involve more precise placement, which can cause longer-lasting redness or lumps.
Safety stands out as a key difference in these injectable treatments. Profhilo's high-purity, uncrossed hyaluronic acid promotes skin hydration and collagen stimulation with minimal risks. Fillers, relying on cross-linked hyaluronic acid, carry potential for complications if injected incorrectly.
Patients often choose based on lifestyle needs. For example, someone with a busy schedule might prefer Profhilo's short downtime for skin rejuvenation. Always consult a qualified injector to assess personal suitability for these non-surgical options.
Risk Profile Comparison
| Aspect | Profhilo | Dermal Fillers |
|---|---|---|
| Downtime | 24 hours | 3-7 days |
| Common Side Effects | 5x BAP marks | Bruising, swelling |
| Serious Risks | None widely reported | Vascular occlusion (reversible with hyaluronidase) |
This table highlights the risk profile differences clearly. Profhilo's BAP technique minimises tissue trauma, leading to faster recovery. Dermal fillers, used for volume restoration like cheek enhancement, may need more time for swelling to subside.
Practical advice includes planning treatments before social events. With Profhilo, patients report returning to work the next day after neck treatment or hands rejuvenation. Fillers for lip augmentation often require makeup to cover bruises initially.
Experts recommend discussing medical history during clinic consultation. This ensures safe choices for anti-aging goals, whether addressing skin laxity or mid-face volume loss.
Safety Data and Approvals
Profhilo holds CE mark approval in Europe and extensive clinical use with no serious adverse events reported across thousands of treatments. Dermal fillers like Juvederm or Restylane have FDA approval but carry a small complication rate from vascular issues. These approvals confirm their place in aesthetic medicine.
Safety stems from formulation differences. Profhilo's thermal stability and diffusion technology allow bio-remodeling without BDDE cross-linking risks. Fillers' cross-linking provides longevity but raises concerns like filler migration or Tyndall effect.
For patient safety, choose dermatologist-recommended providers. Review before-after photos and patient reviews to gauge real outcomes. Combination therapy, pairing Profhilo with fillers, can enhance skin firmness and natural results safely.
Research suggests proper injection technique by qualified professionals reduces all side effects. This applies to both for face protocol or body remodelling like knee laxity treatment.
Cost Comparison
Profhilo full face protocol costs $1,200-$1,800 (2x $600-900 syringes) vs single Juvederm Voluma syringe $700-950, making Profhilo 1.5-2x more expensive initially but covering broader areas. Dermal fillers target specific volume restoration like cheek enhancement, while Profhilo focuses on skin hydration and bio-remodeling across the face. Patients often weigh this against results longevity and maintenance needs.
In major cities, pricing varies by clinic expertise and location. A full Profhilo treatment uses the 2-session protocol at 4-week intervals, promoting collagen stimulation and skin firmness. Juvederm, as a hyaluronic acid filler, suits targeted areas like nasolabial folds but may require more syringes for similar coverage.
Consultation costs add $100-300 upfront, essential for assessing patient suitability with a qualified injector. Maintenance for Profhilo involves a 6-month booster, while fillers need touch-ups every 6-18 months depending on the area. Combination therapy can optimise facial aesthetics but increases total spend.
| Treatment | NYC | London | Sydney |
|---|---|---|---|
| Profhilo full face | $1,600 | £1,200 | AU$2,100 |
| Juvederm 2ml cheeks | $1,500 | £1,100 | AU$1,900 |
ROI considers Profhilo's broader skin rejuvenation improving elasticity and glowy skin versus fillers' focused plumpness. Experts recommend viewing costs through downtime and natural results, as Profhilo's BAP technique minimises sessions.
ROI Analysis
Profhilo offers skin quality benefits through uncrossed hyaluronic acid diffusion, enhancing elastin production over time. Dermal fillers provide immediate volume restoration for hollow cheeks or jawline contouring. Patients see value in Profhilo's regenerative effects lasting up to 6 months with fewer interventions.
Fillers like Juvederm excel in anti-aging for wrinkle reduction but risk lumpiness if overfilled. Profhilo's biorevitalization suits mature skin with laxity, potentially reducing future filler needs. Clinic consultations help compare based on individual aging processes like fat pad descent.
Maintenance pricing impacts long-term ROI, with Profhilo boosters at $600-900 versus filler top-ups per syringe. For body areas like hands rejuvenation, Profhilo covers more ground efficiently. Choose based on goals, such as radiant complexion versus targeted lip augmentation.
Which Treatment is Right for You?
Choose Profhilo for diffuse skin laxity and quality issues, such as in ages 30 to 55 with crepey texture, and dermal fillers for structural volume loss in ages 40 and above, like hollow cheeks or sagging jowls, or combine both using the 'Profhilo foundation + filler sculpture' protocol.
This approach starts with Profhilo's bio-remodelling to boost collagen stimulation and skin hydration, then adds fillers for targeted volume restoration. Patients often see natural results with improved skin firmness and elasticity from the combo.
Consider your main concern, like fine lines or cheek enhancement, and lifestyle factors such as downtime tolerance. A clinic consultation helps match the right injectable treatment to your facial aesthetics goals.
Both options offer minimally invasive skin rejuvenation with low side effects, but treatment duration varies. Experts recommend assessing skin elasticity first for the best fit.
Decision Matrix: Matching Concerns to Treatments
Use this table to compare Profhilo vs dermal fillers based on common issues. It highlights when each excels or if combination therapy suits best.
| Concern | Profhilo | Fillers | Both |
|---|---|---|---|
| Skin texture | ✓ | ✗ | ✓ |
| Cheek volume | ✗ | ✓ | ✓ |
| Duration preference | 6 months | 12-18 months | Varies |
For skin texture like barcode lines or crepiness, Profhilo shines with its uncrossed hyaluronic acid diffusion. Dermal fillers target volume loss in areas like nasolabial folds or temple volume.
Opt for both when seeking wrinkle reduction plus lift, such as mid-face lifting with added plumpness. This matrix guides initial choices before professional advice.
Patient Profiles for Ideal Candidates
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Early agers with skin laxity, like those noticing fine lines around the mouth, benefit most from Profhilo. Its BAP technique with five injection points per side hydrates and firms without volume.
For volume loss patients with hollow cheeks, under-eye hollows, or jowls, dermal fillers provide precise sculpting, such as jawline contouring or lip augmentation.
Comprehensive needs, like mature skin with both texture and structure issues, call for combo use. Think Profhilo for glowy skin base, fillers for definition.
Young skin suits Profhilo for prevention, while advanced cases lean fillers. Always factor in results longevity and maintenance.
Finding a Qualified Injector
Select a qualified injector like a dermatologist experienced in Profhilo and dermal fillers. Look for credentials in aesthetic medicine, such as training in hyaluronic acid cross-linking and bio-remodelling.
- Check for before after photos of similar cases, like neck treatment or hands rejuvenation.
- Verify use of FDA-approved products to avoid risks like filler migration or lumpiness.
- Ask about experience with side effects, downtime, and reversal options like hyaluronidase.
Reputable clinics prioritise patient suitability and custom plans. This ensures natural results in regenerative aesthetics.
Key Questions for Your Consultation
Prepare these to clarify Profhilo vs dermal fillers differences during your visit. They help tailor anti-aging to your needs.
- What is my primary concern, skin hydration or cheek enhancement?
- Do I need the 2-session protocol for Profhilo at 4-week intervals?
- How does injection technique, like subcutaneous injection, affect my downtime?
- What maintenance sessions, such as 6-month boosters, do you recommend?
Discuss cost comparison per syringe and expected skin firmness gains. This leads to informed choices on face protocol or body areas like knee laxity.
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Frequently Asked Questions
Profhilo vs Dermal Fillers: What's the Difference?
Profhilo and dermal fillers are both injectable treatments for skin rejuvenation, but they differ fundamentally. Profhilo is a bio-remodelling treatment using ultrapure hyaluronic acid to hydrate and stimulate collagen and elastin production across larger areas, providing a natural glow without adding volume. Dermal fillers, on the other hand, use hyaluronic acid or other substances to add volume, fill wrinkles, and contour specific areas like lips or cheeks. In short, Profhilo focuses on overall skin quality, while dermal fillers target volume restoration.
What is Profhilo, and how does it compare to dermal fillers?
Profhilo is an injectable hyaluronic acid-based treatment that spreads evenly under the skin to deeply hydrate and bio-remodel it by boosting collagen and elastin. Unlike dermal fillers, which are thicker gels designed to plump and shape targeted spots (e.g., nasolabial folds or jawline), Profhilo doesn't 'fill' but instead improves skin laxity and texture over time with just two sessions spaced a month apart.
Profhilo vs Dermal Fillers: What's the Difference in treatment areas?
The key difference lies in application: Profhilo is ideal for broad areas like the face, neck, hands, and décolletage, where it treats skin quality holistically with only 5 injection points per side of the face. Dermal fillers are precisely placed in specific zones, such as lips, under-eyes, or cheeks, to add structure and volume where targeted enhancement is needed.
How long do results last for Profhilo vs Dermal Fillers?
Profhilo results typically last 6-9 months, with skin improvements continuing due to its collagen-boosting effects, often requiring two treatments initially and one maintenance session yearly. Dermal fillers last 6-18 months depending on the type and area treated, as they physically fill space until the body metabolises them, making Profhilo more about sustained skin health versus fillers' temporary volume.
Profhilo vs Dermal Fillers: What's the Difference in side effects and downtime?
Both are minimally invasive with low downtime, but Profhilo causes milder side effects like slight redness or swelling at 10 injection points, resolving in hours to a day, due to its non-crosslinked hyaluronic acid. Dermal fillers may lead to more bruising, swelling, or lumps at precise injection sites, with downtime up to a few days, especially in delicate areas like lips.
Which is better: Profhilo or Dermal Fillers, and can they be used together?
Neither is universally 'better'—Profhilo excels for overall skin hydration and firmness in patients with mild laxity, while dermal fillers are superior for volume loss or sculpting. Profhilo vs Dermal Fillers: What's the Difference? Ultimately, it's patient-specific. They complement each other perfectly; many combine Profhilo for skin quality first, followed by fillers for targeted volume.
