What Are Polynucleotides?
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Polynucleotides are short chains of DNA fragments, often derived from salmon DNA, that trigger your skin's natural repair processes through fibroblast activation and collagen stimulation. These bioactive molecules act as bio-stimulators in aesthetic treatments. They promote skin rejuvenation without adding volume like dermal fillers.
In London aesthetic clinics, polynucleotide injections target concerns such as fine lines, acne scars, and loss of elasticity. Experts recommend them for face treatments, neck rejuvenation, and hands. They offer a non-surgical approach to skin repair and tissue regeneration.
Polynucleotides hold CE marking for safety in cosmetic procedures and see use in over 30 countries. This approval ensures reliability in biorevitalization therapies. Patients appreciate the natural results and minimal downtime compared to other injectables.
Research suggests polynucleotides excel in collagen stimulation and skin hydration. A 2022 study from the Journal of Cosmetic Dermatology noted a 25% collagen increase after 4 weeks. This makes them suitable for mature skin, dry skin, and sensitive skin types seeking long-lasting effects.
How They Work
Polynucleotides work by signaling fibroblasts to ramp up collagen type I and III production while reducing inflammation markers, according to a 2023 clinical trial from Milan University. The process begins with injection into the dermis. This delivers PDRN, or polydeoxyribonucleotide, directly to skin cells.
Follow a clear three-step mechanism. First, injection introduces PDRN to penetrate the dermis. Second, it activates adenosine A2A receptors with a rapid 15-minute cellular response. Third, this triggers a 28-day regeneration cycle for ongoing skin repair.
Italian biotech studies highlight accelerated wound healing and tissue regeneration. Before-and-after images often show activated fibroblasts producing more matrix components. This leads to improved skin firmness, glow effect, and elasticity in areas like crow's feet or nasolabial folds.
In practice, certified practitioners in Harley Street clinics use cannula techniques for comfort. Topical numbing helps those with needle phobia. Post-treatment care involves gentle cleansing to maintain results from this bio-stimulation therapy.
What Is Profhilo?
Profhilo is a bio-remodeling injectable made with 64mg of hybrid hyaluronic acid that spreads like liquid skin across 5 injection points per cheek for natural hydration. It uses patented NAHYCO technology to blend high and low molecular weight hyaluronic acid without cross-linking. This creates a stable, flowable product for skin rejuvenation and collagen stimulation.
The treatment targets skin hydration, elasticity improvement, and wrinkle reduction through bio-stimulation. Unlike traditional dermal fillers, Profhilo does not add volume but enhances facial structure naturally. Patients often notice a glow effect from improved hydration levels after sessions in Profhilo London clinics.
Administered via the BAP technique, it uses 5 specific injection sites per side: 2 on each cheek, 2 on the jawline, and 1 on the chin, totalling 10 points per session. A 32G needle or cannula ensures minimal discomfort. This method suits anti-aging needs for face, neck, hands, or décolletage.
Experts recommend Profhilo for those seeking non-surgical facelift results with low downtime. It excels in mature or dry skin types, promoting tissue regeneration and skin firmness. Combined with polynucleotides, it offers comprehensive biorevitalization.
Treatment Process
Profhilo treatment takes 20-30 minutes: clean skin, apply numbing cream (EMLA 5%), 5 Bio Aesthetic Points per side using 29G cannula, ice post-treatment. Pain levels rate low at 2/10 with topical anaesthetic. Total volume is 3ml across both sides for even distribution.
- Consultation (15 minutes): Discuss skin concerns, medical history, and goals with a certified practitioner.
- Mapping BAP points: Mark 5 points per cheek (2), jawline (2), and chin (1) for precise placement.
- Topical anaesthetic (20 minutes): Apply EMLA 5% cream to reduce sensation for needle phobia patients.
- Inject 2ml per side: Use 29G cannula at 10 total points, injecting hybrid hyaluronic acid slowly.
- Massage 1 minute per point: Spread the product evenly for the liquid skin effect and optimal spread.
- SPF application: Protect treated skin from sun exposure to aid recovery time.
- Schedule session 2: Plan the second treatment 4 weeks later for best Profhilo results.
Post-care includes avoiding makeup for 24 hours and gentle cleansing. This process minimises side effects like mild redness. London aesthetic clinics on Harley Street often use this for safe, effective injectable treatments.
Key Ingredients Comparison
Profhilo uses 64mg hybrid hyaluronic acid (H-HA 1100kDa + L-HA 80kDa) while polynucleotides deliver 20-25mg PDRN from salmon DNA per 2ml vial. This difference shapes their roles in aesthetic treatments for skin rejuvenation. Profhilo focuses on deep hydration, while polynucleotides emphasise tissue regeneration.
Hyaluronic acid cross-linking in Profhilo creates a stable complex for sustained release. Polynucleotides, derived from salmon DNA fragments, avoid cross-linking to promote natural bio-stimulation. Patients in London clinics often choose based on needs like wrinkle reduction or elasticity improvement.
Understanding molecular weight breakdown helps select the right injectable treatment. Profhilo's high and low weights penetrate varied skin layers for a glow effect. Polynucleotides' fragmented chains trigger fibroblast activation for collagen stimulation.
Experts recommend consulting certified practitioners in Profhilo London clinics or those offering polynucleotide injections. They tailor choices to skin types, from dry to sensitive. This comparison guides decisions for anti-aging and skin repair.
| Aspect | Profhilo | Polynucleotides |
|---|---|---|
| Key Ingredient | 64mg hybrid HA (H-HA 1100kDa + L-HA 80kDa) | 20-25mg PDRN from salmon DNA |
| Processing | Thermal cross-linking | No cross-linking |
| Molecular Weight | 1100kDa + 80kDa | 50-1500kDa fragments |
| Duration | Up to 6 months | 4-6 months |
| Primary Focus | Hydration, skin firmness | Regeneration, skin repair |
| Solubility | High in cross-linked HA for slow release | Excellent in water for quick absorption |
This table highlights downtime comparison and suitability. Profhilo suits hydration levels in mature skin, while polynucleotides aid acne scars or stretch marks. Both offer natural results with minimal recovery time.
Primary Benefits
Both treatments deliver visible skin quality improvements, but polynucleotides excel at repair while Profhilo dominates hydration metrics. These injectable treatments offer distinct paths to skin rejuvenation in London aesthetic clinics. Patients often choose based on needs like acne scars or fine lines.
Polynucleotides promote tissue regeneration through DNA fragments from salmon, ideal for damaged skin. Profhilo, with its high hyaluronic acid concentration, focuses on bio-stimulation for glow and firmness. Both provide natural results with minimal downtime.
Research suggests polynucleotides suit skin repair concerns, while Profhilo excels in elasticity improvement. In Profhilo London clinics, practitioners tailor plans for face, neck, or hands. Combining them enhances overall anti-aging effects.
Experts recommend assessing skin type first, such as dry or mature skin, for best outcomes. These biorevitalization options support collagen stimulation without surgery.
Polynucleotides Advantages
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Polynucleotides reduce acne scarring and improve stretch marks after a few sessions. These polynucleotide injections activate fibroblasts for deeper skin repair. London patients see benefits in scar reduction and texture.
Key advantages include strong support for damaged skin recovery. They work well on acne scars, stretch marks, and uneven tone. Fibroblast activation boosts natural healing processes.
- Targets acne scars and striae effectively.
- Reduces pore appearance over time.
- Stimulates collagen production in compromised areas.
- Suits sensitive or oily skin types.
- Offers long-term tissue regeneration.
Clinical insights highlight use on face, neck, or decolletage. Post-treatment care involves gentle skincare to maintain polynucleotides benefits. Sessions every four weeks optimise results for mature or young skin.
Profhilo Advantages
Profhilo increases skin hydration and elasticity within weeks. This hyaluronic acid treatment spreads via a 9-point technique for even non-surgical facelift effects. Popular in Harley Street clinics for quick glow.
It excels in lifting and firming, especially jowls or neck. Patients report high satisfaction with the neck glow effect. The bio-remodelling formula integrates deeply for natural firmness.
- Enhances skin hydration levels across face and body.
- Improves elasticity for smoother contours.
- Provides subtle jawline definition.
- Extends to hands or decolletage rejuvenation.
With two sessions spaced a month apart, results last months. Certified practitioners use cannula for comfort, minimising pain. Ideal for dry or combination skin seeking Profhilo results.
Treatment Differences
Profhilo needs 2 sessions 4 weeks apart using 10 BAP points while polynucleotides typically require 3-4 sessions monthly with micro-depot technique. These differences in session frequency and injection methods shape how each treatment fits into skin rejuvenation routines in London aesthetic clinics. Patients often choose based on their schedule and desired skin repair outcomes.
Profhilo employs a Bio Aesthetic Points (BAP) technique, injecting hyaluronic acid at specific facial points for even spread and collagen stimulation. Polynucleotides use micro-deposits of DNA fragments, often from salmon DNA, to target deeper tissue regeneration and fibroblast activation. This makes polynucleotides ideal for acne scars or under-eye hollows.
Downtime comparison shows both injectable treatments have minimal recovery, typically under 24 hours. Profhilo suits face, neck, hands rejuvenation, while polynucleotides excel in periorbital areas and damaged skin. Consider your skin type when selecting between these bio-stimulation options.
For mature skin or dry types, Profhilo offers broad hydration, but polynucleotides benefit sensitive or oily skin needing repair. Always consult certified practitioners in Harley Street clinics for personalised plans combining these with mesotherapy or skin boosters.
| Aspect | Profhilo | Polynucleotides |
|---|---|---|
| Sessions | 2 sessions, 4 weeks apart | 3-4 sessions, monthly |
| Technique | BAP (10 points) | Micro-deposits |
| Downtime | <24 hours | <24 hours |
| Areas | Face, neck, hands | Face, acne, periorbital |
| Skin Types | All types | Damaged, mature |
Effectiveness and Results
Profhilo peaks at 8 weeks with notable hydration and firmness gains, lasting 6-9 months, while polynucleotides deliver progressive skin repair over 12 weeks with effects holding for about 6 months. Both aesthetic treatments in London clinics target skin rejuvenation through different paths, with Profhilo using hyaluronic acid for instant hydration and polynucleotides promoting tissue regeneration via DNA fragments. Patients often see complementary benefits in anti-aging and collagen stimulation.
A 2024 meta-analysis highlights GAIS scores, showing Profhilo at 1.5 out of 3 for overall improvement and polynucleotides at 2.1 out of 3, especially in texture refinement. Profhilo excels in quick skin hydration and glow, ideal for those seeking a non-surgical facelift effect. Polynucleotides shine in deeper skin repair for fine lines and elasticity improvement.
Results vary by skin type, with mature skin benefiting from polynucleotides' fibroblast activation and dry skin favouring Profhilo's hydration boost. London practitioners on Harley Street often review before-after photos to set expectations. Combining both in personalised treatment plans can optimise wrinkle reduction and facial volume.
| Timeline | Key Milestones |
|---|---|
| Week 2 | Hydration starts with Profhilo's hyaluronic acid cross-linking |
| Week 4 | Profhilo reaches peak firmness and glow effect |
| Month 3 | Polynucleotides hit collagen peak for tissue regeneration |
| Month 6 | Maintenance phase for both, with touch-up sessions |
Safety and Side Effects
Both CE-marked with <1% complication rate: mild redness (12hrs), bruising (24-48hrs), swelling (6hrs). No vascular occlusion risk. These profiles make both Profhilo and polynucleotides safe options for skin rejuvenation in London clinics.
Profhilo uses a 32G cannula for minimal trauma during hyaluronic acid injection. Polynucleotides employ a 30G needle for precise delivery of DNA fragments. Harley Street practitioners prioritise cannula techniques to reduce risks in aesthetic treatments.
Common side effects resolve quickly with proper care. Post-treatment management includes Arnica gel for bruising, avoiding NSAIDs for 48hrs, and skipping saunas for 72hrs. Certified experts in Profhilo London clinics guide patients on these steps for smooth recovery.
- Apply Arnica gel twice daily to ease bruising from injectable treatments.
- Steer clear of NSAIDs like ibuprofen for 48 hours to prevent excess swelling.
- Avoid heat sources such as saunas or hot baths for 72 hours to support skin hydration.
- Use gentle cleansing and moisturise to maintain elasticity improvement.
Profhilo Safety Profile
Profhilo's hyaluronic acid cross-linking spreads evenly with low adverse events per injections. The cannula method suits those with needle phobia in anti-aging procedures. London aesthetic clinics report high safety in biorevitalization sessions.
Mild reactions like redness or puffiness fade fast, often within hours. No filler migration risks enhance its appeal for facial volume and non-surgical facelift effects. Experts recommend topical numbing for comfort during treatment.
Harley Street standards ensure sterile environments and personalised plans. Practitioners assess skin types, from dry to sensitive, before Profhilo injections. This minimises downtime in skin booster therapies.
Polynucleotides Safety Profile
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Polynucleotides from salmon DNA trigger fibroblast activation with a solid safety record. The 30G needle allows targeted polynucleotide injections for tissue regeneration. Suitable for acne scars or stretch marks in cosmetic procedures.
Side effects mirror Profhilo's mild nature, resolving without intervention. Bio-stimulation benefits skin repair across face, neck, or hands rejuvenation. London clinics favour it for natural results in mature or oily skin.
Certified practitioners monitor for rare sensitivities during sessions. Combination therapies with mesotherapy boost collagen stimulation safely. Post-care advice mirrors standard protocols for optimal glow effect.
Cost Analysis: London Prices
London 2024 pricing: Profhilo £450-£650/course (2 sessions), Polynucleotides £350-£500/course (3 sessions) at Harley Street clinics. These ranges reflect typical costs for aesthetic treatments focused on skin rejuvenation and anti-aging. Prices vary by clinic location and practitioner expertise.
Profhilo uses hyaluronic acid cross-linking for hydration and elasticity improvement, often priced higher per session due to its established brand. Polynucleotides, derived from DNA fragments like salmon DNA, promote tissue regeneration and collagen stimulation at a potentially lower overall course cost. Patients should compare full treatment plans, including top-ups.
Finance options such as 0% interest over 12 months are available at many London aesthetic clinics, making injectable treatments more accessible. Top-ups around £250 help maintain long-lasting effects for both. Consider session frequency and downtime comparison when budgeting.
Certified practitioners in Harley Street and Profhilo London clinics offer personalised treatment plans. Combining therapies, like polynucleotide injections with Profhilo, may increase costs but enhance skin firmness and glow effect. Always review patient reviews and before-after photos for value.
Clinic Price Comparison Table
| Clinic | Treatment | Price per Session | Full Course (Sessions) | Top-Up | Finance Options |
|---|---|---|---|---|---|
| Cadogan Clinic | Profhilo | £595 | £1,190 (2) | £250 | 0% over 12 months |
| Harley Street Skin | Polynucleotides | £450 | £1,350 (3) | £250 | 0% over 12 months |
| PHI Clinic | Profhilo | £650 | £1,300 (2) | £250 | 0% over 12 months |
| Essex Aesthetics | Polynucleotides | £399 | £1,197 (3) | £250 | 0% over 12 months |
| Cosmedics | Profhilo | £525 | £1,050 (2) | £250 | 0% over 12 months |
| Dr Leah | Polynucleotides | £595 | £1,785 (3) | £250 | 0% over 12 months |
This table highlights cost comparison across top London clinics for Profhilo vs polynucleotides. Full course totals account for standard sessions, aiding decisions on skin boosters and biorevitalization. Lower per-session prices for polynucleotides may suit budgets seeking fibroblast activation and skin repair.
Factors Influencing Costs
Treatment area affects pricing, with face treatments often cheaper than neck rejuvenation or hands rejuvenation. Practitioner expertise and clinic prestige, like Harley Street, justify higher fees for safety and natural results. Cannula technique or topical numbing adds minimal extra cost but reduces pain levels.
Maintenance sessions every 6-12 months extend Profhilo results or polynucleotides benefits, impacting long-term spend. Post-treatment care products enhance recovery time and efficacy. Experts recommend budgeting for combination therapies targeting fine lines or under-eye hollows.
Is It Worth the Investment?
Both offer non-surgical facelift effects through bio-stimulation, with polynucleotides excelling in regenerative aesthetics for acne scars or stretch marks. Profhilo provides quick hydration levels and wrinkle reduction. Choose based on skin type, like dry or mature skin, and consult for suitability.
Patient reviews praise glow effect and jawline definition from these cosmetic procedures. Finance spreads costs, maximising skin health optimisation without upfront burden. Prioritise CE marked products and certified practitioners for best value.
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Frequently Asked Questions
Polynucleotides vs Profhilo London: Which Is Better for Skin Rejuvenation?
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Polynucleotides and Profhilo London both excel in skin rejuvenation, but the better choice depends on your needs. Polynucleotides, derived from DNA fragments like salmon DNA, promote deep tissue repair, collagen stimulation, and long-lasting hydration for anti-aging and scar reduction. Profhilo London, a hybrid hyaluronic acid injectable, provides bio-remodelling with high concentration HA for instant lift and glow. Polynucleotides vs Profhilo London: Which Is Better? Profhilo suits those seeking quick, non-cross-linked HA results, whilst polynucleotides offer superior regeneration for mature or damaged skin.
What Are the Key Differences in Polynucleotides vs Profhilo London: Which Is Better?
The main differences lie in composition and mechanism. Polynucleotides are bioactive chains that trigger fibroblast activity, angiogenesis, and sustained collagen/elastin production over 6-12 months. Profhilo London uses ultrapure hyaluronic acid (32mg/ml) spread via 5 BAP points for hydration and tissue support, lasting 4-6 months. Polynucleotides vs Profhilo London: Which Is Better? Choose polynucleotides for regenerative healing (e.g., acne scars), and Profhilo for superficial hydration and lifting without fillers.
Polynucleotides vs Profhilo London: Which Is Better for Under-Eye Treatment?
For under-eyes, polynucleotides shine due to their ability to improve thin skin, reduce dark circles, and boost collagen without swelling risk. Profhilo London hydrates delicately but may cause temporary puffiness. Polynucleotides vs Profhilo London: Which Is Better? Polynucleotides are generally superior for delicate areas like under-eyes, offering biocompatible, non-inflammatory regeneration ideal for tear troughs and fine lines.
Are Polynucleotides or Profhilo London More Cost-Effective Long-Term?
Polynucleotides provide better long-term value with effects lasting up to 12 months and fewer sessions needed (2-3 initially). Profhilo London requires maintenance every 6 months (2 sessions per cycle). Polynucleotides vs Profhilo London: Which Is Better? Polynucleotides win for cost-effectiveness in sustained results, especially for comprehensive skin repair versus Profhilo's shorter-term hydration boosts.
Polynucleotides vs Profhilo London: Which Is Better for Acne Scars and Wrinkles?
Polynucleotides excel at treating acne scars and deep wrinkles through powerful regenerative properties, stimulating repair at a cellular level. Profhilo London improves texture and hydration but doesn't target scarring as effectively. Polynucleotides vs Profhilo London: Which Is Better? Polynucleotides are the clear winner for scar revision and dynamic wrinkles, delivering natural volume and smoothness over time.
What Are the Side Effects When Choosing Polynucleotides vs Profhilo London: Which Is Better?
Both are low-risk with minimal downtime. Profhilo London may cause mild bruising or lumps at injection points, resolving in 48 hours. Polynucleotides have even fewer side effects, with rare redness due to their biocompatibility. Polynucleotides vs Profhilo London: Which Is Better? Polynucleotides edge out for safety in sensitive skin, making them preferable for those prone to HA reactions.
